Reference page — cumulative record through Saturday, October 3, 2026 UTC. Reference pages update as the archive grows; only dated daily editions are immutable pages of record.

CVE-2026-100845

CVE-2026-100845HIGH

Project-MONAI MONAI — MONAI before 1.6.0 Remote Code Execution via NumpyReader

  AV  AC  AT  PR  UI  VC  VI  VA   CVSS    EPSS   %ile   KEV
   L   L   N   N   P   H   H   H    8.5   .0014    3.1     —

AFFECTED
  Product  Versions     Fixed
  MONAI    unspecified  1.6.0

TIMELINE
  Sep 27  Reserved by VulnCheck
  Sep 27  Published (CNA: VulnCheck)
  Sep 30  EXPLOIT PUBLISHED — CVE-2026-100845 (Project-MONAI MONAI). Public exploit reference added.

CWE-502 · CNA: VulnCheck · CVSS v4.0 · 2 references · NVD status: Analyzed

Description

MONAI before 1.6.0 contains an unsafe deserialization vulnerability in the NumpyReader class that unconditionally uses numpy.load with allow_pickle=True when loading .npy and .npz files. Attackers can craft malicious .npy files with pickle payloads that execute arbitrary code when loaded through MONAI's standard data pipeline.

Lifecycle

Complete event history — 3 events, chronological
Date	Event	Detail
September 27, 2026	Reserved	Reserved by VulnCheck
September 27, 2026	Published	Published (CNA: VulnCheck)
September 30, 2026	EXPLOIT PUBLISHED	EXPLOIT PUBLISHED — CVE-2026-100845 (Project-MONAI MONAI). Public exploit reference added.

Affected

Affected products and packages — 1 row
Vendor	Product / Package	Ecosystem	Version introduced	Fixed
Project-MONAI	MONAI	—	—	1.6.0

Weaknesses

CWE-502

References (2)

https://github.com/Project-MONAI/MONAI/security/advisories/GHSA-wg9g-w2j2-8pgr [Exploit, Vendor Advisory]
https://www.vulncheck.com/advisories/monai-before-1.6.0-remote-code-execution-via-numpyreader [Third Party Advisory]

Authoritative record: CVE-2026-100845 at cve.org

Vendors: project-monai

Weaknesses: CWE-502

About this page

This is a reference page, not a dated page of record. It assembles the complete lifecycle of CVE-2026-100845 from the CVE Program record, NVD enrichment, the CISA KEV catalog, EPSS, and OSV advisories. The box score's numbers (CVSS, EPSS, KEV status) are current as of Saturday, October 3, 2026 UTC and are re-derived as the archive grows; only dated daily editions are immutable pages of record. The authoritative source for this identifier is cve.org.